Viruses and the cellular RNA decay machinery

TitleViruses and the cellular RNA decay machinery
Publication TypeJournal Article
Year of Publication2010
AuthorsGaglia M M, Glaunsinger BA
JournalWiley interdisciplinary reviews. RNA
Date Published2010 Jul
KeywordsAnimals, Exoribonucleases, Gene Expression Regulation, Viral, Humans, Models, Biological, Polyadenylation, Protein Biosynthesis, RNA Stability, RNA-Binding Proteins, Viruses
AbstractThe ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens. In eukaryotes, regulation of message stability contributes significantly to the control of gene expression and plays a prominent role in the normal physiology of a cell as well as in its response to environmental and pathogenic stresses. Not surprisingly, emerging evidence indicates that there are significant interactions between the eukaryotic RNA turnover machinery and a wide variety of viruses. Interestingly, in many cases viruses have evolved mechanisms not only to evade eradication by these pathways, but also to manipulate them for enhanced viral replication and gene expression. Given our incomplete understanding of how many of these pathways are normally regulated, viruses should be powerful tools to help deconstruct the complex networks and events governing eukaryotic RNA stability.
Alternate JournalWiley Interdiscip Rev RNA