Read the full article in Cell Host & Microbe article here.
Also check out the accompanying preview article:
Cell Host Microbe. 2015 Aug 12;18(2):144-6. doi: 10.1016/j.chom.2015.07.011.
Do You Believe in ReincaRNAtion? Herpesviruses Reveal Connection between RNA Decay and Synthesis.
Russo J, Wilusz J.
Many viruses degrade host mRNAs to reduce competition for proteins/ribosomes and promote viral gene expression. In this issue of Cell Host & Microbe, Abernathy et al. (2015) demonstrate that a herpesviral RNA endonuclease induces host transcriptional repression that is mediated through the decay factor Xrn1 and evaded by viral genes.