Mechanisms & Consequences of Virus-Induced mRNA Destruction


Related Publications:

Abernathy E, Gilbertson S, Alla R, Glaunsinger B.  2015.  Viral Nucleases Induce an mRNA Degradation-Transcription Feedback Loop in Mammalian CellsCell host & microbe. 18(2):243-53.

Abernathy E, Glaunsinger B.  2015.  Emerging roles for RNA degradation in viral replication and antiviral defenseVirology. 479-480C:600-608.

Abernathy E, Clyde K, Yeasmin R, Krug LT, Burlingame A, Coscoy L, Glaunsinger B.  2014.  Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradationPLoS pathogens. 10(1):e1003882.

Gaglia M M, Covarrubias S, Wong W, Glaunsinger BA.  2012.  A common strategy for host RNA degradation by divergent virusesJournal of virology. 

Richner JM, Clyde K, Pezda AC, Cheng B Y H, Wang T, Kumar RG, Covarrubias S, Coscoy L, Glaunsinger B.  2011.  Global mRNA degradation during lytic gammaherpesvirus infection contributes to establishment of viral latencyPLoS pathogens. 7(7):e1002150.

Kumar RG, Shum L, Glaunsinger BA.  2011.  Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletionMolecular and cellular biology. 31(15):3113-25.

Covarrubias S, Gaglia MM, Kumar RG, Wong W, Jackson AO, Glaunsinger BA.  2011.  Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1PLoS pathogens. 7(10):e1002339.

Gaglia M M, Glaunsinger BA.  2010.  Viruses and the cellular RNA decay machineryWiley interdisciplinary reviews. RNA. 1(1):47-59.

Kumar RG, Glaunsinger BA.  2010.  Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNAMolecular and cellular biology. 30(21):4996-5008.

Covarrubias S, Richner JM, Clyde K, Lee YJ, Glaunsinger BA.  2009.  Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasmJournal of virology. 83(18):9554-66.

Lee YJ, Glaunsinger BA.  2009.  Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destructionPLoS biology. 7(5):e1000107.